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DM100 Series

NanoScale Biomagnetics

DM100 Series nB nanoScale Biomagnetics is a technology based company established in 2008 with the objective of giving an answer to the instrumentation needs of Magnetic Hyperthermia (MHT) research.

The DM100 Series is the first and only one technological solution that can guarantee the highest standards on the quality of measurements that scientific research requires in the field of magnetic heating of nanostructured materials.

The DM100 Series is also the unique integral, immediate and reliable answer to the instrumentation needs of MHT through all its stages: from magnetic characterization to clinical application.
 
Hyperthermia is one of the many clinical protocols used as coadjuvant therapy for cancer treatment. It has demonstrated a clear synergistic effect when combined with radiotherapy, as well as enhancing effects with numerous cytotoxic drugs.
 
Magnetic Hyperthermia uses a combination of alternating magnetic fields (AMF) and magnetic nanoparticles (MNPs) as heating agents. The goal of this approach is to heat specifically and exclusively the local tumor region by means of the magnetic losses of magnetic nanoparticles in an external, alternating magnetic field, doing it without damaging the surrounding healthy tissue.

Regarding the energy loss in the magnetic material, there are two different effects to be considered:
  1. a) magnetic losses through domain wall displacements (in multi-domain particles) called Néel losses; and
    b) energy loss from mechanical rotation of the particles, acting against viscous forces of the liquid medium (Brown losses).
Both effects add up so the lost energy is converted into HEAT.

Magnetic Hyperthermia is usually used as an additive therapy with standard treatments (radiotherapy, for example), and some preliminary studies have showed that the combination of radiation plus hyperthermia lead to increased results regarding tumoral regression.

There are many techniques for hyperthermia involving laser, ionizing radiation, and microwaves as tools to heat up body (malignant) tissues. Although these techniques are capable of rising the intracellular temperature up to the cellular death, they may have unwanted collateral effects such as ionization of genetic material (radiation) or lack of selectiveness (microwaves) that affect the surrounding healthy tissues.
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  • DM2
  • DM3
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Applicator for calorimetry and thermal experiments

DM1 is the only device on the market specially designed for an accurate determination of the physical parameters that describe the heating effects of alternating magnetic fields on magnetic nanosystems.

RF Section
Up to 8 user selectable frequencies from 10KHz to 850KHz.
Up to 300 Oe (23850 A/m) field.
Water cooling connection (chiller not included).

 

Sample Section
Open Dewar flask with vacuum socket.
2ml disposable vial sample holder.

 

Sensors
Optic fiber temperature probe.
Water pressure sensor.

 

Control method
B field user selectable curve.
Sample temperature user selectable curve.
Combined B-T user selectable curve

 

DM1 – Calorimetry

 

The coil diameter in DM1 depends on custom options. It is optimized for each applicator. Anyway, DM1 is not about coil diameter, it is about vial volume: the standard model is for 2ml vial. Field homogeinity for a 2ml sample is better than ±8%. Custom designs can achive up to 2% homogeinity

 

In DM1 (and in DM2 with the dewar option, the CAL) the sample vial is inserted into a dewar with a vacuum chamber. This dewar is an open one, so you have to connect a vacuum pump to achieve good isolation (not included). This vacuum isolation is only for calorimetry purposes.
The cooling of the coil is done for security, stability and reliability purposes, and it is achieved with an external water chiller (not included).


DM1 and DM2 (with CAL) are fine calorimetry systems for SAR determination. Typically, when you apply maximum field, maximum frequency in a pure water sample for about one hour, the temperature variation of the water will be of about 1Kº or 2Kº, depending on the quality of the water chiller, and of course, how carefully the experiment was made regarding previous thermalization and preparation. For a typical SAR experiment (some 10 or 15 minutes) this is a negligible variation.

 

Sample holders in standard DM1 is designed for better precision when filled with 1ml-1,5ml. The minimun recommended is 0,5ml. The smaller the sample, the weaker the signal, so you could, in fact, put less that 0,5ml into the sample vial, but the thermalization between the sample and the vial can be an important source of error for the standard DM1 vial. If the customer is interested in smaller volumes, we could design a sample column for 1ml vials, or less. But again: the smaller the sample, the weaker the signal. It’s not a good idea to work with, for example, 200ul.

Applicator for multiple users

DM2 is the most versatile tool you can imagine for studying the heating effects of alternating magnetic fields on magnetic nanosystems on in vitro, in vivo or new material tests.

RF Section
Up 4 user selectable frequencies from 100KHz to 500KHz.
Up to 200 Gauss/Oersted field.
Water cooling connection (chiller not included).

 

Sample Section
Multiple optional sample holders:
90mm diameter versatile sample chamber.
in vitro, in vivo and calorimetry dewar accessories.

 

Sensors
Fiber optic temperature sensor.
Water pressure sensor.

 

Control method
B field user selectable curve.
Sample temperature user selectable curve.
Combined B-T user selectable curve.

 

Compatible accessories
CAT: Controlled atmosphere accessory for in vitro tests.
CAL: Vacuum dewar flask calorimeter with sensor probe.
HBM: Heartbeat monitor system for small animals.
IR1: Infrared thermal image system.
Custom designed sample holders, probes and accessories.

 

DM2 – Multiple uses


DM2 is the most flexible and developed device of the series. With the addition of current and future accessories it can do IR imaging, calorimetry (like DM1), animal experimentation (like DM3), cell culture experiments, controlled atmosphere and temperature procedures, combined tests, etc.


nB can also design the accessories you imagine for it. Drug release, tissue engineering, material science and many other areas can find in DM2 the best tool for new applications.

Applicator for animal experimentation

DM3 is the only device on the market specially designed for an accurate application of alternating magnetic field, local sensing and experiment monitoring in mice and rats on laboratory hyperthermia procedures.

 

RF Section
4 user selectable frequencies from 80KHz to 450KHz.
(According to user requirements).
Up to 300 Gauss/Oersted field.
Water cooling connection (chiller not included).

 

Sample Section
Animal bed for small mice.
Local and whole body application versions.

 

Sensors
Local temperature sensor.
Systemic temperature sensor.
Water pressure sensor.

 

Control method
B field user selectable curve
Local temperature user selectable control option.
Combined B-T user selectable curve.

 

Compatible accessories
HBM: Heartbeat monitor system for small animals.
IR1: Infrared thermal image system.
Custom designed sample holders, probes and accessories.

 

DM3 – In vivo experimentation

 

The DM3 is better for invivo experiments that any induction coil because DM3 is a controlled environment for in vivo InH (Induction nanoHeating) experiments. Not only it warrantees reliable and repeatable magnetic field parameter, but when combined with some of the available accessories, it allows you to run fully integrated measurements like heart rate, blood pressure, IR thermal imaging, multiple local thermometric probing.


DM2 can be used for animal tests, but it is not the optimal setup for that. These devices, of course, cannot be tilted, so DM2 coil is always vertical. Most researches prefer to do in vivo test in a horizontal position.
If you want to run occasional invivo tests, DM2 can do the job. But if you want to develop a strong research line on clinical hyperthermia or magnetically controlled drug delivery therapies, DM3 is the right tool.

 

DM3 sample chamber can be customized in many ways. The one in the video is an animal bed, open air, with a pancake coil located at the left side of the mouse, where the red disk is shown. In this model, the experiment is at room temperature.

 

DM3 can be customized for many kind of (small) animals. There is not severe limitation for that, and that can be done without special fees.

 

The DM3 you see in the video is not designed for high uniformity but the opposite: strong field over the skin and rapidly fading as measured deeper inside the mouse, since it’s meant for treating surface tumors. But we can build a DM3 according to a customer’s uniformity preferences. Some researchers prefer the same intensity all over the animal, some prefer the field not uniform.

DM100 Accessories allow DM100 series to cover all kinds of Magnetic nanoHeating experiments, from ferrofluid heating to in vitro, ex vivo and in vivo.

 

Infrared imaging, blood pressure sensing, calorimetry, remote sensing, etc, can be integrated to your DM100 Systems using off-the-shelf or custom made accessories.

DM1



DM2



DM3